David L. Spector
Director of Research and Professor
Ph.D., Rutgers University, 1980

Research in my laboratory centers on understanding the spatial organization and regulation of gene expression within the context of the mammalian cell nucleus. In order to study the spatial and temporal aspects of gene expression we developed a live-cell gene expression system that allows us to visualize a stably integrated regulatable genetic locus, and follow in real-time transcription of that locus, including visualization of its mRNA and protein products in living cells. We are also using this as well as an RNA-seq based approach  to assess the transcription and regulation of single copy endogenous genes in mouse embryonic stem cells and neural progenitor cells. A second major focus of our lab is to identify and characterize long nuclear retained non-coding RNAs that play a role in development and/or cancer with the ultimate goal of altering their expression in vivo to impact disease outcome.

Disha Aggarwal

Disha Aggarwal

Graduate Student
Gayatri Arun

Gayatri Arun

Postdoctoral Fellow
Lily Brine

Lily Brine

Research Technician
Gayan Balasooriya

Gayan Balasooriya

Postdoctoral Fellow
Sandra Barrera

Sandra Barrera

Research Technician
Sonam Bhatia

Sonam Bhatia

Postdoctoral Fellow
Kung-Chi Chang

Kung-Chi Chang

Graduate Student
Nour El-amine

Nour El-amine

Research Associate, Manager Microscopy Shared Resource
Rasmani Hazra

Rasmani Hazra

Postdoctoral Fellow
Bodu Liu

Bodu Liu

Postdoctoral Fellow
Suzanne Russo

Suzanne Russo

Research Associate
Madeline Wisnewski

Madeline Wisnewski

Executive Assistant
Wenbo Xu

Wenbo Xu

Graduate Student
Allen Yu

Allen Yu

MD/PhD Student